Recombinant Rat Ascl1, His-tagged
Cat.No. : | Ascl1-3064R |
Product Overview : | Achaete-scute homolog 1 (Ascl1) |
- Specification
- Gene Information
- Related Products
Description : | plays a role in neurogenesis of the autonomic nervous system . |
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 233 |
Purity : | >90% |
Notes : | Small volumes of Ascl1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Ascl1 achaete-scute complex homolog 1 (Drosophila) [ Rattus norvegicus ] |
Official Symbol : | Ascl1 |
Synonyms : | ASCL1; achaete-scute complex homolog 1 (Drosophila); achaete-scute homolog 1; achaete-scute complex homolog-like 1; Mash1; |
Gene ID : | 64186 |
mRNA Refseq : | NM_022384 |
Protein Refseq : | NP_071779 |
Pathway : | Delta-Notch Signaling Pathway, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem; |
Function : | DNA binding; E-box binding; E-box binding; bHLH transcription factor binding; bHLH transcription factor binding; double-stranded DNA binding; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription factor binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
ASCL1-386H | Recombinant Human ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ascl1-1739M | Recombinant Mouse Ascl1 Protein, Myc/DDK-tagged | +Inquiry |
ASCL1-784M | Recombinant Mouse ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ASCL1-474R | Recombinant Rat ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ASCL1-5982C | Recombinant Chicken ASCL1 | +Inquiry |
◆ Lysates | ||
ASCL1-8654HCL | Recombinant Human ASCL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (8)
Ask a questionYes, ASCL1 is associated with several human diseases, including neuroblastoma and small cell lung cancer, where it is often overexpressed and contributes to tumor development.
Yes, ASCL1 is a key regulator of neurogenesis. It acts as a transcription factor that directs the differentiation of neural stem cells into neurons during development.
Yes, ASCL1, in combination with other transcription factors, can induce the reprogramming of somatic cells into neurons in vitro, demonstrating its ability to change cell fate.
Yes, ASCL1 is critical for the formation of several neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.
Although ASCL1 is primarily associated with neural development, it is also expressed in specific regions of the developing lung, where it influences lung neuroendocrine cell differentiation.
ASCL1 is actively being researched as a potential therapeutic target in neuroblastoma and small cell lung cancer. Developing drugs that inhibit ASCL1 may help treat these diseases.
While ASCL1's role in adult neurogenesis is not fully understood, studies suggest that it may play a role in the generation of newborn neurons in certain brain regions, such as the olfactory bulb.
ASCL1 interacts with various proteins involved in neural development and transcriptional regulation, including NEUROD1, TCF3, TLE1, and HDAC1.
Customer Reviews (3)
Write a reviewTheir collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
the manufacturer's support is crucial for researchers using ASCL1 protein in trials.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ASCL1 protein in their studies.
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