Recombinant Rat Apom, His-tagged
Cat.No. : | Apom-3577R |
Product Overview : | Apolipoprotein M (Apom) |
- Specification
- Gene Information
- Related Products
Description : | human homolog is a lipoprotein associated with high density lipoprotein (HDL) particles . |
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 190 |
Purity : | >90% |
Notes : | Small volumes of Apom recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Apom apolipoprotein M [ Rattus norvegicus ] |
Official Symbol : | Apom |
Synonyms : | APOM; apolipoprotein M; apo-M; protein Px; |
Gene ID : | 55939 |
mRNA Refseq : | NM_019373 |
Protein Refseq : | NP_062246 |
Function : | binding; lipid transporter activity; lipid transporter activity; molecular_function; |
Products Types
◆ Recombinant Protein | ||
APOM-2209M | Recombinant Mouse APOM Protein (1-190 aa), His-tagged | +Inquiry |
APOM-2471H | Recombinant Human APOM Protein, MYC/DDK-tagged | +Inquiry |
APOM-516D | Recombinant Dog APOM Protein, His-tagged | +Inquiry |
Apom-521R | Recombinant Rat Apom Protein, His-tagged | +Inquiry |
APOM-385R | Recombinant Rat APOM Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
APOM-1594HCL | Recombinant Human APOM cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (12)
Ask a questionYes, genetic variations in the APOM gene can impact APOM protein levels. Certain single nucleotide polymorphisms (SNPs) or mutations within the APOM gene have been associated with altered APOM expression levels. For example, specific APOM gene variants have been linked to lower APOM protein levels in plasma and changes in HDL cholesterol levels, which may contribute to cardiovascular disease risk.
APOM protein is mainly expressed in the liver and kidneys. It is also present in other tissues, such as the intestines, adrenal glands, and spleen, but at lower levels.
Yes, there are several known regulators of APOM protein expression. Transcription factors, such as hepatocyte nuclear factor 1 (HNF-1), liver X receptors (LXRs), and peroxisome proliferator-activated receptor gamma (PPARγ), have been identified as regulators of APOM gene expression. Additionally, factors like insulin, statins, and sex hormones (such as estrogen) can also influence APOM protein levels.
Yes, APOM protein can interact with other proteins and molecules. In addition to binding to S1P, APOM has been shown to interact with components of the HDL particle, such as apolipoprotein A-I (apoA-I). It can also interact with enzymes involved in the metabolism of lipids, such as sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate lyase (S1PL), which regulate S1P levels.
APOM protein has been investigated as a potential biomarker for certain diseases. Research suggests that APOM levels in plasma or HDL particles could be used as a biomarker for evaluating cardiovascular risk and predicting the progression of metabolic disorders. However, further studies are needed to establish its utility as a clinical biomarker.
Yes, there are several known genetic variants and mutations in the APOM gene. Some studies have linked certain APOM gene variants to altered levels of APOM protein, which can impact lipid metabolism and the risk of developing cardiovascular diseases.
Given the role of APOM protein in lipid metabolism and its association with cardiovascular diseases, it has been considered as a potential drug target. However, no specific drugs targeting APOM are currently available. Further research is needed to explore potential therapeutic strategies aimed at modulating APOM levels or function for clinical applications.
Currently, there are no approved therapeutic strategies specifically targeting APOM protein. However, given its involvement in lipid metabolism and cardiovascular health, manipulating APOM levels or function could hold therapeutic potential. Future research may explore approaches such as gene therapy, potential drug candidates, or interventions aimed at modulating APOM expression or its interaction with S1P to potentially impact lipid disorders and cardiovascular diseases.
APOM protein has been implicated in various diseases, particularly those related to lipid metabolism and cardiovascular health. For example, low levels of APOM in HDL particles have been associated with increased risk of atherosclerosis, coronary artery disease, and impaired glucose metabolism.
Yes, APOM protein can influence the composition of HDL particles. Its binding to S1P within HDL can modify the lipid content and structure of these particles. This, in turn, can impact the functionality and biological properties of HDL, such as its ability to promote reverse cholesterol transport and exert anti-inflammatory effects.
APOM protein binds to sphingosine-1-phosphate (S1P) and helps transport it within high-density lipoprotein (HDL) particles. This interaction with APOM stabilizes S1P and allows it to circulate in the bloodstream, playing a role in various biological processes, including immune cell trafficking, angiogenesis, and vascular biology.
APOM protein is involved in several cellular processes, including lipid metabolism, lipoprotein biogenesis and remodeling, immune cell activation and migration, endothelial cell integrity, and vascular homeostasis. Its interaction with S1P and its role in HDL metabolism have implications for various physiological and pathological processes, such as atherosclerosis, inflammation, and cardiovascular health.
Customer Reviews (4)
Write a reviewSecuring a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the APOM protein offered by the manufacturer will fulfill my requirements.
This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.
the APOM protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.
Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.
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