Recombinant Mouse Il17a

• Cat.No.: Il17a-12M
• Product Overview: Mouse IL-17A was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

Specification

• Description: IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family members are involved in numerous immune regulatory functions, including inducing and mediating proinflammatory responses and allergic responses. IL-17 induces the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta, and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1 (CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).
• Source: Yeast
• Species: Mouse
• Form: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Molecular Mass: Mouse IL-17A has a predicted molecular weight of 15.0 kDa.
• AA Sequence: AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA (133)
• Purity: >95% as visualized by SDS-PAGE analysis.
• Applications: The Mouse IL-17A protein can be used in cell culture, as a IL-17A ELISA Standard, and as a Western Blot Control.
• Storage: Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: Il17a interleukin 17A [ Mus musculus (house mouse) ]
• Official Symbol: Il17a
• Synonyms: Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8
• Gene ID: 16171
• mRNA Refseq: NM_010552
• Protein Refseq: NP_034682
• UniProt ID: Q62386
• Chromosome Location: 1; 1 A
• Pathway: Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Rheumatoid arthritis
• Function: cytokine activity