Recombinant Human TIMP1 Protein, MBP-tagged

• Cat.No.: TIMP1-001H
• Product Overview: Recombinant Human TIMP1 Protein (1-207 aa (full-length)) with MBP tag was expressed in E. coli.

Specification

• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
• Source: E. coli
• Species: Human
• Tag: MBP
• Molecular Mass: 67.8 kDa
• Protein length: 1-207
• Purity: >90% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB).
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB), immunoblotting with anti-MBP (WB) and peptide fingerprinting by MALDI-TOF mass spectrometry.
• Storage: Store working aliquots at 4 centigrade for up to one week.For extended storage, conserve at −80 centigrade.
• Expiry: 12 months from the date of purchase, if it is properly stored.
• Storage Buffer: 20mM Tris-HCl , 0.2M NaCl, 1 mM EDTA and 10mM Maltose, pH: 7.4. No preservatives added.
• Shipping: Dry Ice

Gene Information

• Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens (human) ]
• Official Symbol: TIMP1
• Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; TIMP-1; metalloproteinase inhibitor 1; collagenase inhibitor
  epididymis secretory sperm binding protein; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
• Gene ID: 7076
• mRNA Refseq: NM_003254
• Protein Refseq: NP_003245
• MIM: 305370
• UniProt ID: P01033