Active Recombinant Rat Il22, HIgG1 Fc-tagged
Cat.No. : | Il22-001R |
Product Overview : | The extracellular domain of rat IL-22 (ABF82262.1)(Leu27-Val172) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | IL22 (interleukin 22) is a protein-coding gene. Diseases associated with IL22 include chronic mucocutaneous candidiasis, and candidiasis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity and interleukin-22 receptor binding. |
Source : | CHO cell |
Species : | Rat |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | The Biological Activity was determined by the ability to activiate STAT following receptor ligand interaction. |
Molecular Mass : | 42KDa (monomer) |
AA Sequence : | Leu27-Val172 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | Il22 interleukin 22 [ Rattus norvegicus ] |
Official Symbol : | Il22 |
Synonyms : | IL22; interleukin 22; interleukin-22; RGD1561292; |
Gene ID : | 500836 |
mRNA Refseq : | NM_001191988 |
Protein Refseq : | NP_001178917 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | molecular_function; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for Th17 differentiation.
Effective in gut repair assays.
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