Active Recombinant Human Il15, HIgG1 Fc-tagged, mutant

• Cat.No.: Il15-001H
• Product Overview: The extracellular domain of human IL-15 (NP_751914.1)(Asn49-Ser162) including mutations at Q149D and Q156D is fused to the N-terminus of the Fc region of mutant human IgG1was expressed in CHO cell.

Specification

• Description: IL15 (interleukin 15) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with IL15 include gamma chain deficiency, and rasmussen encephalitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine receptor binding and cytokine activity.
• Source: CHO cell
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay.
• Molecular Mass: 39KDa (monomer)
• AA Sequence: Asn49-Ser162 including mutations at Q149D and Q156D
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL15 interleukin 15 [ Homo sapiens ]
• Official Symbol: IL15
• Synonyms: IL15; interleukin 15; interleukin-15; IL 15; MGC9721; IL-15
• Gene ID: 3600
• mRNA Refseq: NM_000585
• Protein Refseq: NP_000576
• MIM: 600554
• UniProt ID: P40933
• Chromosome Location: 4q31
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem
• Function: cytokine activity; cytokine receptor binding; protein binding