Active Recombinant Human SEMA5A, MIgG2a Fc-tagged

• Cat.No.: SMA5A-3511H
• Product Overview: The extracellular domain of human SEMA5A (AAI15697.1) (Glu23-Thr765) is fused to the N-terminus of the Fc region of mouse lgG2a was expressed in CHO cell.

Specification

• Description: This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain andseveral thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neuraldevelopment. This gene has been implicated as an autism susceptibility gene
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit proliferation.
• Molecular Mass: 110KDa (monomer)
• AA Sequence: Glu23-Thr765
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Homo sapiens ]
• Official Symbol: SEMA5A
• Synonyms: SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; SEMAF; semaphorin-5A; semF; sema F; semaphorin F; semaphorin-F; FLJ12815
• Gene ID: 9037
• mRNA Refseq: NM_003966
• Protein Refseq: NP_003957
• MIM: 609297
• UniProt ID: Q13591
• Chromosome Location: 5p15.2
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Other semaphorin interactions, organism-specific biosystem; Semaphorin interactions, organism-specific biosystem
• Function: axon guidance receptor activity; receptor activity