Active Recombinant Human Chemokine (C-X-C Motif) Ligand 10, MIgG2a Fc-tagged
Cat.No. : | CXCL10-211H |
Product Overview : | The extracellular domain of human CXCL10 (AAH10954.1)(Val22-Pro98) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
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Description : | This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. |
Source : | CHO cell |
Species : | Human |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to chemoattract BaF3 mouse pro-B cells. |
Molecular Mass : | 35KDa (monomer) |
AA Sequence : | Val22-Pro98 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | CXCL10 chemokine (C-X-C motif) ligand 10 [ Homo sapiens ] |
Official Symbol : | CXCL10 |
Synonyms : | CXCL10; chemokine (C-X-C motif) ligand 10; INP10, SCYB10, small inducible cytokine subfamily B (Cys X Cys), member 10; C-X-C motif chemokine 10; C7; crg 2; gIP 10; IFI10; IP 10; mob 1; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; |
Gene ID : | 3627 |
mRNA Refseq : | NM_001565 |
Protein Refseq : | NP_001556 |
MIM : | 147310 |
UniProt ID : | P02778 |
Chromosome Location : | 4q21 |
Pathway : | CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cAMP-dependent protein kinase regulator activity; chemokine activity; receptor binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCXCL10 affects the blood-brain barrier, playing a role in neuroinflammatory disorders.
CXCL10 plays a role in autoimmune diseases, exacerbating conditions like rheumatoid arthritis and lupus.
In cancer, CXCL10 influences the tumor microenvironment and may contribute to tumor spread and metastasis.
Changes in CXCL10 expression influence chronic inflammatory diseases, potentially aggravating or modulating disease progression.
CXCL10 is important in antiviral defense, enhancing immune responses against pathogens like hepatitis viruses and HIV.
CXCL10 impacts angiogenesis and is involved in tissue repair and regeneration processes.
CXCL10 attracts and activates immune cells to sites of inflammation and infection, coordinating the immune response.
Customer Reviews (3)
Write a reviewExpertise in protein engineering, invaluable for our laboratory's needs.
Swift protein characterization services, essential for our research projects.
High-quality protein-protein interaction assays, integral to our experiments.
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