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Active Recombinant Human interleukin 8, MIgG2a Fc-tagged

Cat.No. : CXCL8-321H
Product Overview : The extracellular domain of human IL-8 (NP_000575.1)(Ala23-Ser99) is fused to the N-terminus of the Fc portion of mouse IgG2a was expressed in CHO cell.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q
Source : CHO cell
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its chemotaxis of human CXCR-2 transfected mouse BaF/3 cells.
Molecular Mass : 37 KDa (monomer)
AA Sequence : Ala23-Ser99
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : CXCL8
Official Symbol : CXCL8
Synonyms : IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Gene ID : 3576
mRNA Refseq : NM_000584
Protein Refseq : NP_000575
MIM : 146930
UniProt ID : P10145
Chromosome Location : 4q13-q21
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Activation of Genes by ATF4, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem;
Function : chemokine activity; interleukin-8 receptor binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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