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Active Recombinant Human Decorin, HIgG1 Fc-tagged

Cat.No. : DCN-1702H
Product Overview : The extracellular domain of human Decorin (AAH05322.1)(Pro18-Lys359) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
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Description : The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely relatedin structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a geneduplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a rolein matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing thegrowth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for thisgene. This gene is a candidate gene for Marfan syndrome.
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to modulate collagen fibrillogenesis.
Molecular Mass : 64kDa (monomer)
AA Sequence : Pro18-Lys359
Endotoxin : ≤0.06EU/μg as determined by LAL test.
Purity : ≥98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : DCN decorin [ Homo sapiens ]
Official Symbol : DCN
Synonyms : DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II; CSCD; PG40; PGII; PGS2;
Gene ID : 1634
mRNA Refseq : NM_001920
Protein Refseq : NP_001911
MIM : 125255
UniProt ID : P07585
Chromosome Location : 12q23
Pathway : TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem;
Function : collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein N-terminus binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the effect of targeted DCN delivery on tumor growth in a mouse model of breast cancer? 07/10/2022

Targeted DCN delivery in breast cancer models reduces tumor growth.

How does DCN modulate TGF-β signaling at the molecular level? 05/06/2022

DCN modulates TGF-β signaling, affecting fibrosis and cancer development.

How do variations in the glycosaminoglycan chains attached to DCN influence its interaction with growth factors? 12/11/2021

Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.

What are the cellular and molecular consequences of DCN gene silencing in fibroblasts? 12/07/2021

DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.

How do mechanical forces influence the function and localization of DCN in the cardiac extracellular matrix? 04/30/2021

Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.

Which proteins are differentially expressed in cells overexpressing DCN compared to control cells? 10/14/2019

Overexpression of DCN changes protein expression related to cell growth and matrix interactions.

What is the detailed three-dimensional structure of DCN when bound to collagen? 07/27/2018

DCN bound to collagen reveals binding sites essential for collagen structure.

Customer Reviews (3)

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Reviews
03/11/2020

    Excellent support for protein purification. Highly recommend this service.

    11/01/2019

      Efficient protein expression, quick turnaround time, and reliable results.

      10/14/2019

        Outstanding antibody validation; trustworthy for protein-protein interaction studies.

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