Active Recombinant Human Decorin, HIgG1 Fc-tagged
Cat.No. : | DCN-1702H |
Product Overview : | The extracellular domain of human Decorin (AAH05322.1)(Pro18-Lys359) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely relatedin structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a geneduplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a rolein matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing thegrowth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for thisgene. This gene is a candidate gene for Marfan syndrome. |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to modulate collagen fibrillogenesis. |
Molecular Mass : | 64kDa (monomer) |
AA Sequence : | Pro18-Lys359 |
Endotoxin : | ≤0.06EU/μg as determined by LAL test. |
Purity : | ≥98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | DCN decorin [ Homo sapiens ] |
Official Symbol : | DCN |
Synonyms : | DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II; CSCD; PG40; PGII; PGS2; |
Gene ID : | 1634 |
mRNA Refseq : | NM_001920 |
Protein Refseq : | NP_001911 |
MIM : | 125255 |
UniProt ID : | P07585 |
Chromosome Location : | 12q23 |
Pathway : | TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem; |
Function : | collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein N-terminus binding; |
Products Types
◆ Recombinant Protein | ||
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DCN-815H | Recombinant Human DCN Protein, His-tagged | +Inquiry |
DCN-1377M | Recombinant Mouse DCN Protein (35-354 aa), His-tagged | +Inquiry |
DCN-1455R | Recombinant Rat DCN Protein, His (Fc)-Avi-tagged | +Inquiry |
DCN-73H | Recombinant Human DCN protein(Asp31-Lys359), hFc-tagged | +Inquiry |
◆ Lysates | ||
DCN-2274HCL | Recombinant Human DCN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTargeted DCN delivery in breast cancer models reduces tumor growth.
DCN modulates TGF-β signaling, affecting fibrosis and cancer development.
Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.
DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.
Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.
Overexpression of DCN changes protein expression related to cell growth and matrix interactions.
DCN bound to collagen reveals binding sites essential for collagen structure.
Customer Reviews (3)
Write a reviewExcellent support for protein purification. Highly recommend this service.
Efficient protein expression, quick turnaround time, and reliable results.
Outstanding antibody validation; trustworthy for protein-protein interaction studies.
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