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Active Recombinant Human SEMA4D, HIgG1 Fc-tagged

Cat.No. : SEMA4D-512H
Product Overview : The extracellular domain of human CD100 (AAH54500.1) (Met22-Arg734) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell
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  • Gene Information
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Description : SEMA4D (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D) is a protein-coding gene. Diseases associated with SEMA4D include soft tissue sarcoma, and cleft palate, and among its related super-pathways are Sema4D in semaphorin signaling and Axon guidance. GO annotations related to this gene include transmembrane signaling receptor activity and receptor binding. An important paralog of this gene is SEMA3C.
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit survival of SKOV3 human ovarian carcinoma cells.
Molecular Mass : 105KDa (monomer)
AA Sequence : Met22-Arg734
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [ Homo sapiens ]
Official Symbol : SEMA4D
Synonyms : SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; C9orf164, chromosome 9 open reading frame 164 , SEMAJ; semaphorin-4D; CD100; coll 4; FLJ39737; M sema G; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; coll-4; C9orf164; M-sema-G; FLJ33485; FLJ34282; FLJ46484; MGC169138; MGC169141;
Gene ID : 10507
mRNA Refseq : NM_001142287
Protein Refseq : NP_001135759
MIM : 601866
UniProt ID : Q92854
Chromosome Location : 9q22-q31
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Sema4D in semaphorin signaling, organism-specific biosystem; Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem; Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem;
Function : protein binding; receptor activity; receptor binding; semaphorin receptor binding; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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