Active Recombinant Human ICOSLG, MIgG2a Fc-tagged

• Cat.No.: ICOSLG-1213H
• Product Overview: The extracellular domain of human CD275[B7-H2] (NP_056074.1) (Met1-Thr256) is fused to the N-terminus of the Fc region of mouse IgG2a.

Specification

• Description: ICOSLG (inducible T-cell co-stimulator ligand) is a protein-coding gene. Diseases associated with ICOSLG include inclusion body myositis, and myositis, and among its related super-pathways are Immune System and Immune response ICOS pathway in T-helper cell. GO annotations related to this gene include receptor binding.
• Source: CHO cells
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to stimulate human T cell proliferation in the presence of anti-CD3.
• Molecular Mass: 52 KDa (monomer)
• AA Sequence: Met1-Thr256
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: ICOSLG inducible T-cell co-stimulator ligand [ Homo sapiens ]
• Official Symbol: ICOSLG
• Synonyms: ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L
• Gene ID: 23308
• mRNA Refseq: NM_015259
• Protein Refseq: NP_056074
• MIM: 605717
• UniProt ID: O75144
• Chromosome Location: 21q22.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
• Function: receptor binding