Active Recombinant Human CD276, HIgG1 Fc-tagged

• Cat.No.: CD276-2002H
• Product Overview: The extracellular domain of human B7-H3 (NP_079516.1) (Leu29-Pro245) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.

Specification

• Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in theregulation of T-cell-mediated immune response. Studies show that while the transcript of this gene isubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumortissues. Additionally, it was observed that the 3" UTR of this transcript contains a target site for miR29microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggestingregulation of expression of this gene product by miR29. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene.
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
• Molecular Mass: 49KDa (monomer)
• AA Sequence: Leu29-Pro245
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CD276 CD276 molecule [ Homo sapiens ]
• Official Symbol: CD276
• Synonyms: CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3
• Gene ID: 80381
• mRNA Refseq: NM_001024736
• Protein Refseq: NP_001019907
• MIM: 605715
• UniProt ID: Q5ZPR3
• Chromosome Location: 15q23-q24
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem
• Function: protein binding; receptor binding