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Active Recombinant Human EGF, HIgG1 Fc-tagged

Cat.No. : EGF-551H
Product Overview : The extracellular domain of human EGF (NP_001954.2) (Asn971-Arg1023) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
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Description : This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as alarge precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factorpeptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferationand differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor,epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation ofthis gene has been associated with the growth and progression of certain cancers. Alternate splicing results inmultiple transcript variants
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.2-1ng/mL.
Molecular Mass : 32 KDa (monomer)
AA Sequence : Asn971-Arg1023
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : EGF epidermal growth factor [ Homo sapiens ]
Official Symbol : EGF
Synonyms : EGF; epidermal growth factor; epidermal growth factor (beta urogastrone); pro-epidermal growth factor; beta-urogastrone; URG; HOMG4;
Gene ID : 1950
mRNA Refseq : NM_001178130
Protein Refseq : NP_001171601
MIM : 131530
UniProt ID : P01133
Chromosome Location : 4q25
Pathway : Arf6 signaling events, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Ceramide signaling pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem;
Function : calcium ion binding; epidermal growth factor receptor binding; growth factor activity; protein binding; transmembrane receptor protein tyrosine kinase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is EGF protein produced in the body? 02/07/2022

The body naturally produces EGF protein, and it can also be synthesized for clinical applications using biotechnological methods.

Are there any side effects associated with the clinical use of EGF protein? 12/06/2021

Generally, EGF is well-tolerated, but localized irritation or redness at the application site can occur in some cases.

Can EGF be used in the treatment of burns? 11/03/2021

Yes, EGF has been explored for its potential in treating burns by promoting the regeneration of damaged skin tissue.

What are the primary clinical applications of EGF protein? 10/19/2021

EGF protein is widely used in clinical settings for wound healing, tissue regeneration, and certain dermatological conditions.

Is EGF used in cosmetic products, and if so, for what purpose? 09/28/2019

Yes, EGF is a common ingredient in some cosmetic products due to its ability to promote skin rejuvenation and reduce the appearance of fine lines and wrinkles.

Customer Reviews (3)

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Reviews
01/27/2020

    This can be advantageous in understanding disease mechanisms and developing novel therapeutics.

    04/12/2018

      The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

      05/09/2016

        The manufacturer can offer technical expertise and guidance to researchers regarding the proper use, handling, and storage of EGF protein.

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