Active Recombinant Human il2, MIgG2a Fc-tagged, mutant

• Cat.No.: IL2-168H
• Product Overview: The extracellular domain of mouse IL-2 (NP_032392.1)(Ala21-Gln169) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell.

Specification

• Description: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and Blymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also sharedby interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeteddisruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential roleof this gene in the immune response to antigenic stimuli
• Source: NS1 cells
• Species: Mouse
• Tag: MIgG2a Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg*.
• Molecular Mass: 46KDa (monomer)
• AA Sequence: Ala21-Gln169
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il2 interleukin 2 [ Mus musculus ]
• Official Symbol: IL2
• Synonyms: IL2; interleukin 2; interleukin-2; TCGF; T-cell growth factor; Il-2
• Gene ID: 16183
• mRNA Refseq: NM_008366
• Protein Refseq: NP_032392
• Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem
• Function: carbohydrate binding; cytokine activity; cytokine activity; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding