Active Recombinant Mouse Ctla4, MIgG2a Fc-tagged, mutant
Cat.No. : | Ctla4-333M |
Product Overview : | The extracellular domain of mouse CD152 [CTLA-4] (NP_033973.2)(Met1-Ser160) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene |
Source : | NS1 cells |
Species : | Mouse |
Tag : | MIgG2a Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Blocks the binding of mouse CD80 (B7-1) and CD86 (B7-2) to their receptors (by binding CD80 and CD86 with high affinity) and thereby prevents their T cell regulatory actions by inhibiting the CD28 signaling competitively. Shows the biological functions of |
Molecular Mass : | 44 KDa |
AA Sequence : | Met1-Ser160 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | ≥98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus ] |
Official Symbol : | Ctla4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4; Cd152; Ly-56; Ctla-4; |
Gene ID : | 12477 |
mRNA Refseq : | NM_009843 |
Protein Refseq : | NP_033973 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; |
Products Types
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Ctla4-651H | Recombinant Human Ctla4 Protein, IgG2a Fc-tagged | +Inquiry |
CTLA4-653M | Recombinant Mouse CTLA4 Protein | +Inquiry |
CTLA4-257H | Active Recombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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