Active Recombinant Human IL27, HIgG1 Fc-tagged, mutant

• Cat.No.: IL27-124H
• Product Overview: The human IL-27 complex composed of the Ebi3 subunit(NP_005746.2) (Arg21-Lys229) and the p28 subunit(NP_663634.2)(Val26-Pro243) is fused through a polypeptide linker to the Fc region of a mutant human IgG1was expressed in CHO cell

Specification

• Description: The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein isrelated to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similarto interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but notmemory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferongamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by theclass I cytokine receptor (WSX1/TCRR).
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.
• Molecular Mass: 78 KDa (monomer)
• AA Sequence: Arg21-Lys229
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL27 interleukin 27 [ Homo sapiens ]
• Official Symbol: IL27
• Synonyms: IL27; interleukin 27
• Gene ID: 144841