Active Recombinant Human IL6,HIgG1 Fc-tagged, mutant

• Cat.No.: IL6-312H
• Product Overview: The extracellular domain of human IL-6 (NP_000591.1)(Val30-Met212) is fused to the N-terminus of the Fc region of a mutant human IgG1was expressed in CHO cell

Specification

• Description: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, theencoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmunediseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it issecreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states,including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by the dose-dependent stimulation of the proliferation of IL-6 dependent mouse 7TD1 cells
• Molecular Mass: 47 KDa (monomer)
• AA Sequence: Val30-Met212
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]
• Official Symbol: IL6
• Synonyms: IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6
• Gene ID: 3569
• mRNA Refseq: NM_000600
• Protein Refseq: NP_000591
• MIM: 147620
• UniProt ID: P05231
• Chromosome Location: 7p21-p15
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem
• Function: cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; contributes_to interleukin-6 receptor binding; interleukin-6 receptor binding