Recombinant Human CYP1A1

• Cat.No.: CYP1A1-550H
• Product Overview: Recombinant Human Cytochrome P450 1A1 Isozyme Microsomes, with P450 Reductase was expressed in baculovirus infected insect cells. Microsomes containing human CYP1A1 and recombinant human NADPH-P450 reductase.

Specification

• Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme"s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
• Source: baculovirus infected insect cells
• Species: Human
• Form: Solution in 100 mM potassium phosphate buffer, pH 7.4.
• Storage: ?70°C

Gene Information

• Gene Name: CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [ Homo sapiens (human) ]
• Official Symbol: CYP1A1
• Synonyms: CYP1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450 1A1; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; NP_000490.1; EC 1.14.14.1
• Gene ID: 1543
• mRNA Refseq: NM_000499
• Protein Refseq: NP_000490
• MIM: 108330
• UniProt ID: P04798
• Chromosome Location: 15q24.1
• Pathway: AhR pathway; Benzo(a)pyrene metabolism; Chemical carcinogenesis
• Function: aromatase activity; heme binding; iron ion binding