Active Recombinant Human CYP1B1
Cat.No. : | CYP1B1-552H |
Product Overview : | Recombinant Human Cytochrome P450 1B1 Isozyme Microsomes, with P450 Reductase was expressed in baculovirus infected insect cells. Microsomes containing human CYP1B1 and recombinant human NADPH-P450 reductase. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. |
Source : | baculovirus infected insect cells |
Species : | Human |
Form : | Solution in 100 mM potassium phosphate buffer, pH 7.4. |
Bio-activity : | Tested for the ability to catalyze the 7-deethylation of ethoxyresorufin. |
Storage : | ?70°C |
Publication : |
CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae (2021)
|
Gene Name : | CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 [ Homo sapiens (human) ] |
Official Symbol : | CYP1B1 |
Synonyms : | CYP1B1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); NP_000095.2; EC 1.14.14.1 |
Gene ID : | 1545 |
mRNA Refseq : | NM_000104 |
Protein Refseq : | NP_000095 |
MIM : | 601771 |
UniProt ID : | Q16678. |
Chromosome Location : | 2p22.2 |
Pathway : | AhR pathway; Benzo(a)pyrene metabolism; Chemical carcinogenesis |
Function : | aromatase activity; heme binding; iron ion binding |
Products Types
◆ Recombinant Protein | ||
CYP1B1-01H | Active Recombinant Human CYP1B1 Protein | +Inquiry |
CYP1B1-120D | Active Recombinant Dog CYP1B1 Protein | +Inquiry |
CYP1B1-2127M | Recombinant Mouse CYP1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Cyp1b1-123M | Active Recombinant Mouse Cyp1b1 Protein | +Inquiry |
CYP1B1-962R | Recombinant Rhesus Macaque CYP1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CYP1B1-7125HCL | Recombinant Human CYP1B1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionIt plays a key role in detoxifying environmental carcinogens and pollutants.
CYP1B1 works alongside other P450 enzymes, contributing to a broad spectrum of metabolic processes.
Genetic mutations in CYP1B1 can lead to variations in metabolism, influencing drug response and toxicity.
Altered CYP1B1 activity is associated with an increased risk of certain cancers, due to its role in metabolizing carcinogens.
Targeting CYP1B1 offers potential for cancer prevention and treatment, particularly in managing hormone-related cancers.
CYP1B1, part of the cytochrome P450 family, is essential for metabolizing various drugs and chemicals.
CYP1B1 is involved in the metabolism of steroid hormones, affecting their synthesis and breakdown.
Customer Reviews (3)
Write a reviewTrustworthy data source. A critical research asset.
Reliable partner in experiments. Enhances research quality.
Dependable results. A research cornerstone.
Ask a Question for All CYP1B1 Products
Required fields are marked with *
My Review for All CYP1B1 Products
Required fields are marked with *
Inquiry Basket