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Active Recombinant Human CYP1B1

Cat.No. : CYP1B1-552H
Product Overview : Recombinant Human Cytochrome P450 1B1 Isozyme Microsomes, with P450 Reductase was expressed in baculovirus infected insect cells. Microsomes containing human CYP1B1 and recombinant human NADPH-P450 reductase.
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  • Gene Information
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Source : baculovirus infected insect cells
Species : Human
Form : Solution in 100 mM potassium phosphate buffer, pH 7.4.
Bio-activity : Tested for the ability to catalyze the 7-deethylation of ethoxyresorufin.
Storage : ?70°C
Publication :
CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae (2021)
Gene Name : CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 [ Homo sapiens (human) ]
Official Symbol : CYP1B1
Synonyms : CYP1B1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); NP_000095.2; EC 1.14.14.1
Gene ID : 1545
mRNA Refseq : NM_000104
Protein Refseq : NP_000095
MIM : 601771
UniProt ID : Q16678.
Chromosome Location : 2p22.2
Pathway : AhR pathway; Benzo(a)pyrene metabolism; Chemical carcinogenesis
Function : aromatase activity; heme binding; iron ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CYP1B1 contribute to the metabolism of environmental toxins? 08/29/2022

It plays a key role in detoxifying environmental carcinogens and pollutants.

How does CYP1B1 interact with other cytochrome P450 enzymes? 07/24/2022

CYP1B1 works alongside other P450 enzymes, contributing to a broad spectrum of metabolic processes.

How do genetic variations in CYP1B1 affect its enzymatic function? 12/24/2021

Genetic mutations in CYP1B1 can lead to variations in metabolism, influencing drug response and toxicity.

What is the impact of altered CYP1B1 activity on cancer risk? 09/09/2021

Altered CYP1B1 activity is associated with an increased risk of certain cancers, due to its role in metabolizing carcinogens.

What potential therapeutic applications arise from targeting CYP1B1 in diseases? 03/22/2020

Targeting CYP1B1 offers potential for cancer prevention and treatment, particularly in managing hormone-related cancers.

What is the primary role of CYP1B1 in drug metabolism? 12/30/2017

CYP1B1, part of the cytochrome P450 family, is essential for metabolizing various drugs and chemicals.

What role does CYP1B1 play in steroid hormone synthesis? 07/07/2017

CYP1B1 is involved in the metabolism of steroid hormones, affecting their synthesis and breakdown.

Customer Reviews (3)

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Reviews
03/15/2021

    Trustworthy data source. A critical research asset.

    02/15/2018

      Reliable partner in experiments. Enhances research quality.

      04/03/2017

        Dependable results. A research cornerstone.

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