| Description : |
IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity. |
| Source : |
Yeast |
| Species : |
Swine |
| Form : |
Lyophilized without carrier protein. |
| Molecular Mass : |
Swine IL-21 has a predicted molecular weight of 15.0 kDa. |
| AA Sequence : |
HKSSFQGQDR LLIRLRQLID TVDQLKNYVH DLDPELLPAP EDVQRHCEQS AFSCFQKVEL KSANTGDNEK IINVLIKQLK RKLPPTNAGR RQKHGLTCPT CDSYEKKPIK EFLERLKSLI QKMIHQHLS |
| Purity : |
>95% as visualized by SDS-PAGE analysis. |
| Applications : |
The Swine IL-21 protein can be used in cell culture, as an IL-21 ELISA Standard, and as a Western Blot Control. |
| Storage : |
Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles. |
| Reconstitution : |
Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
