Recombinant Human PCMT1, His-tagged
Cat.No. : | PCMT1-704H |
Product Overview : | Recombinant human PCMT1 protien, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 28.8 kDa (263aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | PCMT1-704H |
Description : | PCMT1, also known as L-isoaspartyl protein carboxyl methyltransferase, is an enzyme that catalyses the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. This protein plays a role in the repair and/or degradation of damaged proteins. |
Source : | E.coli. |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAWK SGGASHSELI HNLRKNGIIK TDKVFEVMLA TDRSHYAKCN PYMDSPQSIG FQATISAPHM HAYALELLFD QLHEGAKALD VGSGSGILTA CFARMVGCTG KVIGIDHIKE LVDDSINNVR KDDPTLLSSG RVQLVVGDGR MGYAEEAPYD AIHVGAAAPV VPQALIDQLK PGGRLILPVG PAGGNQMLEQ YDKLQDGSIK MKPLMGVIYV PLTDKEKQWS RWK. |
Storage : | can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Publication : |
Ser 422 phosphorylation blocks human Tau cleavage by caspase-3: Biochemical implications to Alzheimer’s Disease (2017)
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Gene Name : | PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase [ Homo sapiens ] |
Synonyms : | protein-L-isoaspartate (D-aspartate) O-methyltransferase; PCMT1; protein-L-isoaspartate(D-aspartate) O-methyltransferase; PIMT; OTTHUMP00000017397; OTTHUMP00000017398; OTTHUMP00000017400; protein-beta-aspartate methyltransferase; L-isoaspartyl/D-aspartyl methyltransferase; L-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase;protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; Protein-beta-aspartate methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; EC 2.1.1.77 |
Gene ID : | 5110 |
mRNA Refseq : | NM_005389 |
Protein Refseq : | NP_005380 |
MIM : | 176851 |
UniProt ID : | P22061 |
Chromosome Location : | 6q24-q25 |
Function : | identical protein binding; methyltransferase activity; protein binding; transferase activity; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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