Recombinant Human Insulin-like Growth Factor Binding Protein 5
Cat.No. : | IGFBP5-81H |
Product Overview : | Recombinant Human IGFBP5 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 253 amino acids and having a molecular mass of 28613 Dalton. IGFBP5 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IGFBP5-81H |
Description : | IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Source : | Escherichia Coli. |
Amino Acid sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Gly-Ser-Phe. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10 mM sodium Citrate PH 3.0. |
Solubility : | It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-5 in sterile 18 MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Specific Activity : | The ED50, calculated by its ability to inhibit IGF-II induced proliferation of MCF-7 is < 0.3µg/ml in the presence of 15 ng/ml of Human IGF-II. |
Stability : | Lyophilized IBP5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP 5 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | IGFBP5 insulin-like growth factor binding protein 5 [ Homo sapiens ] |
Synonyms : | IBP-5; IBP5; IGFBP-5; IGFBP5; IGF-binding protein 5; insulin-like growth factor binding protein 5 |
Gene ID : | 3488 |
mRNA Refseq : | NM_000599 |
Protein Refseq : | NP_000590 |
MIM : | 146734 |
UniProt ID : | P24593 |
Chromosome Location : | 2q33-q36 |
Pathway : | Diabetes pathway |
Function : | insulin-like growth factor I binding |
Products Types
◆ Recombinant Protein | ||
IGFBP5-361H | Active Recombinant Human IGFBP5 Protein (Met1-Glu272), His-tagged | +Inquiry |
IGFBP5-4430H | Recombinant Human IGFBP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Igfbp5-10572M | Recombinant Mouse Igfbp5 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP5-2666R | Recombinant Rat IGFBP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGFBP5-172C | Recombinant Canine IGFBP5 protein(Met1-Glu271), hFc-tagged | +Inquiry |
◆ Lysates | ||
IGFBP5-001CCL | Recombinant Canine IGFBP5 cell lysate | +Inquiry |
IGFBP5-764CCL | Recombinant Cynomolgus IGFBP5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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