Recombinant Human ARNT, MYC/DDK-tagged
Cat.No. : |
ARNT-19H |
Product Overview : |
Recombinant Human ARNT, fused with C-terminal MYC/DDK, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : |
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. |
Source : |
HEK293 cells |
Species : |
Human |
Tag : |
MYC/DDK |
Molecular Mass : |
35.8 kDa |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : |
>50 ug/mL as determined by microplate BCA method |
Storage Buffer : |
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : |
ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens (human) ] |
Official Symbol : |
ARNT |
Synonyms : |
ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta |
Gene ID : |
405 |
mRNA Refseq : |
NM_178426 |
Protein Refseq : |
NP_848513 |
MIM : |
126110 |
UniProt ID : |
P27540 |
Chromosome Location : |
1q21 |
Pathway : |
AhR pathway; Cellular response to hypoxia; HIF-1 signaling pathway |
Function : |
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; aryl hydrocarbon receptor activity; enhancer binding |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.