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Active Recombinant Human GCSF

Cat.No. : GCSF-89H
Product Overview : Recombinant Human GCSF produced in CHO cells is a single, glycosylated, polypeptide chain containing 174 amino acids and having a molecular mass of approximately 18 kDa. G-CSF is purified by proprietary chromatographic techniques.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene.
Source : CHO
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder. G-CSF was lyophilized from a concentrated (1mg/ml) Phosphate- Buffered Saline, pH 7.4.
Bio-activity : The ED50, calculated by the dose-dependant proliferation of murine NFS-60 indicator cells (measured by 3H-thymidine uptake) is < 0.07 ng/ml, corresponding to a Specific Activity of 1.27 x 10^8 IU/mg.
Molecular Mass : 18 kDa
AA Sequence : TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP.
Purity : Greater than 97.0% as determined by RP-HPLC and SDS-PAGE.
Stability : Lyophilized Granulocyte Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution G-CSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized Granulocyte Colony Stimulating Factor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : CSF3 colony stimulating factor 3 (granulocyte) [ Homo sapiens (human) ]
Official Symbol : CSF3
Synonyms : CSF3; GCSF; CSF3OS; C17orf33; colony stimulating factor 3 (granulocyte); granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin
Gene ID : 1440
mRNA Refseq : NM_000759
Protein Refseq : NP_000750
MIM : 138970
UniProt ID : P09919
Chromosome Location : 17q11.2-q12
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Function : cytokine activity; enzyme binding; granulocyte colony-stimulating factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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