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Active Recombinant Human PRCP, His-tagged

Cat.No. : PRCP-23H
Product Overview : Recombinant Human PRCP (Met1-His496), fused with a C-terminal 6-His tag, was expressed in Mouse NSO Cells.
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Description : The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Leu22
Form : Supplied as a 0.2 µm filtered solution in MES and NaCl.
Bio-activity : Measured by its ability to cleave the synthetic peptide substrate N-benzyloxycarbonyl-Pro-Ala (Z-Pro-Ala).
Molecular Mass : Predicted Molecular Mass: 54 kDaSDS-PAGE: 60-70 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name : PRCP prolylcarboxypeptidase (angiotensinase C) [ Homo sapiens ]
Official Symbol : PRCP
Synonyms : PRCP; prolylcarboxypeptidase (angiotensinase C); lysosomal Pro-X carboxypeptidase; HUMPCP; PCP; angiotensinase C; proline carboxypeptidase; lysosomal carboxypeptidase C; prolylcarboxypeptidase isoform 1 preproprotein; MGC2202
Gene ID : 5547
mRNA Refseq : NM_005040
Protein Refseq : NP_005031
MIM : 176785
UniProt ID : P42785
Chromosome Location : 11q14
Pathway : Formation of Fibrin Clot (Clotting Cascade); Hemostasis; Protein digestion and absorption; Intrinsic Pathway
Function : protein binding; serine-type carboxypeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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