Recombinant Human Placental Growth Factor

• Cat.No.: PGF-98H
• Product Overview: Recombinant Human Placenta Growth Factor-2 produced ininsect cellsis a homodimer, glycosylated polypeptide chain containing 2 x 152 amino acids and having a total molecular mass of 44 kDa. The PLGF-2 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: PGF-98H
• Description: PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner.
• Source: Insect Cells
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 80.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Lyophilized from a concentrated (1 mg/ml) solution containing BSA.
• Solubility: It is recommended to reconstitute the lyophilized Placenta Growth Factor 2 in sterile 20 mM acetic acid not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
• Specific Activity: PlGF-2 human Recombinant can bind to immobilized rh-sFlt-1 (100 ng/well) with a linear range at 0.3 – 10 ng/mL.
• Stability: Lyophilized Placenta Growth Factor-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PLGF2 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: PGF placental growth factor [ Homo sapiens ]
• Synonyms: PGF; PLGF; PlGF-2; PIGF; PGFL; D12S1900; SHGC-10760; Placenta growth factor; Placental growth factor; Factor-related protein; Placental growth factor-like; Placental growth factor, vascular endothelial growth; Placental growth factor, vascular endothelial growth factor-related protein
• Gene ID: 5228
• mRNA Refseq: NM_002632
• Protein Refseq: NP_002623
• MIM: 601121
• UniProt ID: P49763
• Chromosome Location: 14q24-q31
• Pathway: Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; mTOR signaling pathway
• Function: Growth factor activity; Heparin binding; Protein binding; Protein heterodimerization activity; Protein homodimerization activity