Recombinant Human casein kinase 2, alpha 1 polypeptide
Cat.No. : | CSNK2A1-21H |
Product Overview : | Recombinant Human Casein Kinase 2 alpha is a non-glycosylated polypeptide having a molecular mass of 45.1 kDa. Casein Kinase 2 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CSNK2A1-21H |
Description : | The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Disheveled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2. Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm. |
Source : | Escherichia Coli. |
Unit Definition : | No protease activity detectable, specific activity > 1.320 U/mg (1U = 1µmol/min at 37 degree C) using the synthetic peptide RRRDDDSDDD. |
Physical Appearance : | Sterile Filtered clear solution. |
Purity : | Greater than 99% as determined by SDS-PAGE. |
Formulation : | CK2 (0.4 mg/ml) is supplied in 25mM Tris-HCl, 500mM NaCl, 1mM DTT, 500μM PMSF, 50% glycerol, pH 8.5. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
Gene Name : | CSNK2A1 casein kinase 2, alpha 1 polypeptide [ Homo sapiens ] |
Synonyms : | CSNK2A1; casein kinase 2, alpha 1 polypeptide; CKII; CK2A1; casein kinase II alpha 1 subunit; protein kinase CK2; CK2 catalytic subunit alpha; EC 2.7.11.1; OTTHUMP00000029925; OTTHUMP00000029926 |
Gene ID : | 1457 |
mRNA Refseq : | NM_001895 |
Protein Refseq : | NP_001886 |
MIM : | 115440 |
UniProt ID : | P68400 |
Chromosome Location : | 20p13 |
Pathway : | Adherens junction; Tight junction; Wnt signaling pathway |
Function : | ATP binding; nucleotide binding; protein N-terminus binding; protein serine/threonine kinase activity; transferase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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