Recombinant Human c-src tyrosine kinase
Cat.No. : | CSK-27H |
Product Overview : | Recombinant Human CSRC produced inSf9 cellsis a glycosylated, polypeptide chain having a molecular mass of 60 KD. CSRC is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CSK-27H |
Description : | SRC family kinases are involved in transducing growth factor signals for cellular differentiation and proliferation in a variety of cell types. The activity of all Src family kinases (SFKs) is controlled by phosphorylation at their C-terminal 527-tyrosine residue by C-terminal SRC kinase, CSK. The C-terminal SRC kinase (CSK) family of protein tyrosine kinases contains two members: CSK and CSK homologous kinase (CHK). Both phosphorylate and inactivate SRC family kinases. C-terminal SRC kinase (CSK) contains a catalytic domain and a regulatory region, consisting of an SH3 and an SH2 domain. |
Source : | Sf9 Insect Cells. |
Physical Appearance : | Sterile Filtered clear solution. |
Purity : | Greater than 95% as determined by SDS-PAGE. |
Formulation : | C-SRC is supplied at a concentration of 0.29mg/ml in 50mM Tris, pH 7.6, 0.15 M NaCl, 0.27M sucrose, 1mM DTT, 0.1mM EGTA, 0.2mM PMSF, 1mM benzamidine, 5mM NaF, 10mM β-glycerol phosphate, 0.1mM sodium vanadate and 0.03% Brij-35. |
Biological Activity : | 750 units/mg. One unit of C-SRC activity is equal to 1 nmol of phosphate transferred to a peptide corresponding to p34cdc2 (6-20) per minute at 30°C with a final ATP concentration of 100 µM. Recombinant human active C-SRC also phosphorylates STAT, p34cdc2, gastrin, and cortactin.Please note: Kinase activity may vary depending on the substrate and reaction conditions. |
Storage : | Store at 4°C if entire vial will be used within 1-2 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
Gene Name : | CSK c-src tyrosine kinase [ Homo sapiens ] |
Synonyms : | CSK; c-src tyrosine kinase; MGC117393; EC 2.7.10.2; C-SRC kinase ; Protein-tyrosine kinase CYL |
Gene ID : | 1445 |
mRNA Refseq : | NM_001127190 |
Protein Refseq : | NP_001120662 |
MIM : | 124095 |
UniProt ID : | P41240 |
Chromosome Location : | 15q23-q25 |
Pathway : | Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Neurotrophin signaling pathway; Regulation of actin cytoskeleton |
Function : | ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity |
Products Types
◆ Recombinant Protein | ||
CSK-882R | Recombinant Rhesus Macaque CSK Protein, His (Fc)-Avi-tagged | +Inquiry |
CSK-1979H | Recombinant Human CSK Protein, GST-tagged | +Inquiry |
CSK-0765H | Recombinant Human CSK Protein (M1-L450), GST tagged | +Inquiry |
CSK-3345H | Recombinant Human CSK Protein, MYC/DDK-tagged | +Inquiry |
CSK-1286R | Recombinant Rat CSK Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
CSK-27872TH | Native Human CSK | +Inquiry |
◆ Lysates | ||
CSK-001MCL | Recombinant Mouse CSK cell lysate | +Inquiry |
CSK-628HCL | Recombinant Human CSK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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