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Recombinant Human NOTUM 293 Cell Lysate

Cat.No. : NOTUM-3754HCL
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Description : Antigen standard for notum pectinacetylesterase homolog (Drosophila) (NOTUM) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : NOTUM notum pectinacetylesterase homolog (Drosophila) [ Homo sapiens ]
Official Symbol : NOTUM
Synonyms : NOTUM; notum pectinacetylesterase homolog (Drosophila); protein notum homolog;
Gene ID : 147111
mRNA Refseq : NM_178493
Protein Refseq : NP_848588
MIM : 609847
UniProt ID : Q6P988
Chromosome Location : 17q25.3
Function : hydrolase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In neurological disorders, how does NOTUM protein contribute to therapeutic interventions? 12/03/2022

NOTUM's role in Wnt signaling modulation has implications for neurodegenerative disorders, and targeting NOTUM may offer therapeutic avenues for conditions such as Alzheimer's disease.

How does NOTUM protein affect stem cell function? 10/17/2020

NOTUM is involved in the regulation of stem cell behavior through its influence on Wnt signaling, making it a target for manipulating stem cell activities.

Are there any ongoing clinical trials exploring NOTUM-targeted therapies? 08/03/2020

Several clinical trials are underway to investigate the safety and efficacy of NOTUM inhibitors in cancer patients, providing valuable insights into their clinical potential.

How does NOTUM protein influence tissue homeostasis? 01/31/2018

NOTUM's role in regulating Wnt signaling contributes to tissue homeostasis, and understanding this mechanism can provide insights into maintaining tissue health.

How can NOTUM protein be utilized in personalized medicine approaches? 04/27/2016

Understanding individual variations in NOTUM expression and activity may allow for personalized treatment strategies, tailoring interventions based on a patient's molecular profile.

Customer Reviews (3)

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Reviews
08/26/2021

    Its excellent performance in ELISA assays makes it a valuable tool in quantifying analytes in biological samples.

    11/09/2020

      Its reliability, specificity, and versatility make it an invaluable asset in studying and understanding complex biological systems.

      07/20/2020

        Its usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.

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