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Recombinant Human MAP2K3 293 Cell Lysate

Cat.No. : MAP2K3-4511HCL
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  • Gene Information
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Description : Antigen standard for mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant A is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : MAP2K3 mitogen-activated protein kinase kinase 3 [ Homo sapiens ]
Official Symbol : MAP2K3
Synonyms : MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3; SAPK kinase 2; stress-activated protein kinase kinase 2; SAPKK2; SAPKK-2;
Gene ID : 5606
mRNA Refseq : NM_002756
Protein Refseq : NP_002747
MIM : 602315
UniProt ID : P46734
Chromosome Location : 17q11.2
Pathway : Activated TLR4 signalling, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDC42 signaling events, organism-specific biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem;
Function : ATP binding; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MAP2K3 serve as a prognostic marker for certain diseases? 12/21/2021

Evidence suggests that MAP2K3 expression levels can correlate with disease prognosis, aiding in predicting outcomes for some cancers.

Are there any ongoing clinical trials targeting MAP2K3 for therapeutic purposes? 05/31/2020

Clinical trials investigating the efficacy of targeting MAP2K3 in cancer treatments are underway, assessing its potential as a therapeutic target.

In which cancer types is MAP2K3 dysregulation commonly observed? 04/13/2019

MAP2K3 dysregulation has been observed in various cancers, including colorectal, lung, and breast cancers.

Are there specific inhibitors or drugs targeting MAP2K3? 01/10/2019

While specific inhibitors for MAP2K3 are under development, some drugs indirectly impact its activity by targeting related proteins in the signaling cascade.

How is MAP2K3 expression levels studied in a clinical setting? 02/17/2016

Expression levels of MAP2K3 can be assessed through techniques like immunohistochemistry or molecular analyses in patient samples.

Customer Reviews (3)

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Reviews
01/08/2022

    The manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.

    04/26/2021

      They offer comprehensive technical support, including responsive customer service, availability of product information, and timely delivery of the product.

      05/13/2017

        MAP2K3 protein offers numerous advantages in trials, ranging from its stability and bioactivity to the manufacturer's commitment to customer support.

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