Recombinant Human GSDMD 293 Cell Lysate
Cat.No. : | GSDMD-5725HCL |
- Specification
- Gene Information
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Description : | Antigen standard for gasdermin D (GSDMD), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | GSDMD gasdermin D [ Homo sapiens ] |
Official Symbol : | GSDMD |
Synonyms : | GSDMD; gasdermin D; gasdermin domain containing 1 , GSDMDC1; gasdermin-D; DF5L; FLJ12150; gasdermin domain containing 1; gasdermin domain-containing protein 1; DFNA5L; FKSG10; GSDMDC1; |
Gene ID : | 79792 |
mRNA Refseq : | NM_001166237 |
Protein Refseq : | NP_001159709 |
UniProt ID : | P57764 |
Chromosome Location : | 8q24.3 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionStudies have suggested that the expression levels of GSDMD protein may be associated with disease severity and prognosis in certain inflammatory conditions, indicating its potential as a prognostic marker.
Mutations in the GSDMD gene have been associated with autoinflammatory disorders, such as familial Mediterranean fever, which presents with recurrent episodes of fever and inflammation.
Various signaling pathways and post-translational modifications regulate the activity of GSDMD protein, contributing to its involvement in the pathogenesis of inflammatory diseases.
The inflammasome, a multiprotein complex that regulates inflammatory responses, activates GSDMD protein to induce pyroptosis and release of pro-inflammatory cytokines, contributing to the pathogenesis of inflammatory diseases.
Targeting GSDMD protein could lead to the development of diagnostic tools for detecting and monitoring inflammatory diseases, providing valuable insights for patient management.
Customer Reviews (3)
Write a reviewWhether I need to study protein-protein interactions, protein localization, or protein folding, the GSDMD protein consistently delivers precise and meaningful data.
the GSDMD protein's compatibility with various experimental techniques further supports its usability.
One of the standout features of the GSDMD protein is the excellent technical support provided by the manufacturer.
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