Recombinant Human PROC
Cat.No. : | PROC-32H |
Product Overview : | Recombinant Human Activated Protein C produced inCHOis a disulfide-linked homodimeric, glycosylated, polypeptide chain having a molecular mass of 55kDa. Activated Protein C Human Recombinant is a serine protease with the same amino acid sequence and glycosilation sites as the human plasma-derived Activated Protein C. The APC is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Cat. No. : | PROC-32H |
Description : | Activated Protein C exerts an antithrombotic effect by inhibiting Factors Va and VIIIa. In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. Additionally, in vitro data indicate that Activated Protein C may exert an anti-inflammatory effect by inhibiting human tumor necrosis factor production by monocytes, by blocking leukocyte adhesion to selectins, and by limiting the thrombin-induced inflammatory responses within the microvascular endothelium. |
Source : | Chinese Hamster Ovary Cells (CHO). |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | Each mg protein contains 7. 6 mg sodium chloride, 1.5 mg citrate and 6 mg sucrose. |
Solubility : | It is recommended to reconstitute the lyophilized Coagulation factor V in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Stability : | Lyophilized Factor V although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ] |
Synonyms : | PROC; protein C (inactivator of coagulation factors Va and VIIIa); PC; PROC1;Vitamin K-dependent protein C;Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV;Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; EC 3.4.21.69; protein C; protein C (inactivator of coagulation factors Va and VIIIa) |
Gene ID : | 5624 |
mRNA Refseq : | NM_000312 |
Protein Refseq : | NP_000303 |
UniProt ID : | P04070 |
Chromosome Location : | 2q13-q14 |
MIM : | 612283 |
Pathway : | Complement and coagulation cascades; Hemostasis; Metabolism of proteins; aling in Immune system |
Function : | calcium ion binding; peptidase activity; protein binding; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
PROC-1772H | Recombinant Human PROC Protein, His (Fc)-Avi-tagged | +Inquiry |
Proc-5137M | Recombinant Mouse Proc Protein, Myc/DDK-tagged | +Inquiry |
PROC-4368R | Recombinant Rat PROC Protein, His (Fc)-Avi-tagged | +Inquiry |
PROC-2432R | Recombinant Rat PROC Protein (42-461 aa), His-tagged | +Inquiry |
PROC-3000H | Recombinant Human PROC Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
PROC-272B | Active Native Bovine Activated Protein C | +Inquiry |
PROC-269B | Active Native Bovine Protein C | +Inquiry |
PROC-273B | Active Native Bovine Protein C - DEGR (active site blocked) | +Inquiry |
◆ Lysates | ||
PROC-747MCL | Recombinant Mouse PROC cell lysate | +Inquiry |
PROC-852HCL | Recombinant Human PROC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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