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Recombinant Human PROC

Cat.No. : PROC-32H
Product Overview : Recombinant Human Activated Protein C produced inCHOis a disulfide-linked homodimeric, glycosylated, polypeptide chain having a molecular mass of 55kDa. Activated Protein C Human Recombinant is a serine protease with the same amino acid sequence and glycosilation sites as the human plasma-derived Activated Protein C. The APC is purified by proprietary chromatographic techniques.
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Cat. No. : PROC-32H
Description : Activated Protein C exerts an antithrombotic effect by inhibiting Factors Va and VIIIa. In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. Additionally, in vitro data indicate that Activated Protein C may exert an anti-inflammatory effect by inhibiting human tumor necrosis factor production by monocytes, by blocking leukocyte adhesion to selectins, and by limiting the thrombin-induced inflammatory responses within the microvascular endothelium.
Source : Chinese Hamster Ovary Cells (CHO).
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Each mg protein contains 7. 6 mg sodium chloride, 1.5 mg citrate and 6 mg sucrose.
Solubility : It is recommended to reconstitute the lyophilized Coagulation factor V in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Stability : Lyophilized Factor V although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
Synonyms : PROC; protein C (inactivator of coagulation factors Va and VIIIa); PC; PROC1;Vitamin K-dependent protein C;Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV;Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; EC 3.4.21.69; protein C; protein C (inactivator of coagulation factors Va and VIIIa)
Gene ID : 5624
mRNA Refseq : NM_000312
Protein Refseq : NP_000303
UniProt ID : P04070
Chromosome Location : 2q13-q14
MIM : 612283
Pathway : Complement and coagulation cascades; Hemostasis; Metabolism of proteins; aling in Immune system
Function : calcium ion binding; peptidase activity; protein binding; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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