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Recombinant Human ADRM1 293 Cell Lysate

Cat.No. : ADRM1-8996HCL
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Description : Antigen standard for adhesion regulating molecule 1 (ADRM1), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : ADRM1 adhesion regulating molecule 1 [ Homo sapiens ]
Official Symbol : ADRM1
Synonyms : ADRM1; adhesion regulating molecule 1; proteasomal ubiquitin receptor ADRM1; ARM1; GP110; Rpn13; ARM-1; hRpn13; rpn13 homolog; M(r) 110,000 surface antigen; adhesion-regulating molecule 1; regulatory particle non-ATPase 13; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13; MGC29536;
Gene ID : 11047
mRNA Refseq : NM_175573
Protein Refseq : NP_783163
MIM : 610650
UniProt ID : Q16186
Chromosome Location : 20q13.33
Function : endopeptidase activator activity; protease binding; proteasome binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is the expression level of ADRM1 protein regulated under normal physiological conditions? 09/16/2022

The expression level of ADRM1 protein is regulated at the transcriptional and post-transcriptional levels by various cellular factors.

Are there any known post-translational modifications of ADRM1 protein and how do they affect its function? 04/21/2022

Post-translational modifications, including phosphorylation and ubiquitination, have been identified on ADRM1 protein, which can modulate its stability and function.

What are the specific cellular processes or pathways in which ADRM1 protein is involved? 03/09/2021

ADRM1 protein is primarily involved in the regulation of protein degradation through the ubiquitin-proteasome system.

What are the downstream targets or substrates of ADRM1 protein, and what are the consequences of their interaction? 08/28/2020

ADRM1 protein interacts with ubiquitinated proteins, serving as a receptor to deliver them to the proteasome for degradation.

Are there any pharmacological agents or small molecules that can modulate the activity or expression of ADRM1 protein? 08/04/2017

Some pharmacological agents, such as proteasome inhibitors, can affect the activity of ADRM1 protein indirectly by modulating the overall proteasome function. However, specific small molecules targeting ADRM1 directly are currently under investigation.

How does ADRM1 protein contribute to the development or progression of specific diseases or disorders? 06/06/2017

Dysregulation of ADRM1 protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.

Are there any genetic or epigenetic factors that influence the expression or activity of ADRM1 protein? 01/25/2017

Genetic and epigenetic factors can influence the expression and activity of ADRM1 protein, although specific regulatory mechanisms are still being elucidated.

What experimental techniques have been used to study the function of ADRM1 protein? 10/02/2016

Various experimental techniques, such as protein-protein interaction assays, immunoprecipitation, and mass spectrometry, have been used to study the function of ADRM1 protein.

Can ADRM1 protein be localized to specific cellular compartments or structures? 04/05/2016

ADRM1 protein is mainly localized to the cytoplasm and is associated with the 26S proteasome.

Can ADRM1 protein interact with other proteins or participate in protein complexes? 01/25/2016

Yes, ADRM1 protein can interact with other proteins and participate in protein complexes involved in protein degradation processes.

Customer Reviews (3)

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Reviews
09/16/2017

    Exploring protein-protein interactions involved in viral infections.

    03/09/2017

      Detecting protein-protein interactions in multiprotein complexes.

      01/28/2017

        Understanding protein-protein interaction networks in chromatin remodeling.

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