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Recombinant Human FTCD, His-tagged

Cat.No. : FTCD-37H
Product Overview : Recombinant Human Formiminotransferase Cyclodeaminase (also called liver cytosol type 1) produced inSf9, is a glycosylated, polypeptide chain having a molecular mass of 59,749 Dalton. The FTCD is expressed with a -6x His tag and purified by proprietary chromatographic techniques.
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Cat. No. : FTCD-37H
Description : Formiminotransferase cyclodeaminase is an enzyme which catalyzes the conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate. Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker). Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury.
Source : Sf9 insect cells.
Purity : Greater than 95% as determined by SDS-PAGE.
Formulation : FTCD is supplied at a concentration of 0.5 mg/ml in 16mM HEPES buffer pH-7.6, 240 mM sodium chloride, and 20% glycerol.
Immunological Functions : 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels, immuno-dot test).
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody.and autoimmune hepatitis (AIH II) patient sera.
Coating Concentration : 0.35-0.7 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : FTCD formiminotransferase cyclodeaminase [ Homo sapiens ]
Synonyms : FTCD; formiminotransferase cyclodeaminase; LCHC1;EC=2.1.2.5;EC=4.3.1.4; Formimidoyltransferase-cyclodeaminase; Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; human formiminotransferase cyclodeaminase, EC 4.3.1.4; OTTHUMP00000115563
Gene ID : 10841
mRNA Refseq : NM_006657
Protein Refseq : NP_006648
MIM : 606806
UniProt ID : O95954
Chromosome Location : 21q22.3
Pathway : Histidine metabolism; Metabolic pathways; One carbon pool by folate; Metabolism of amino acids
Function : folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; lyase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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