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Recombinant Human ABL2 293 Cell Lysate

Cat.No. : ABL2-9126HCL
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  • Gene Information
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Description : Antigen standard for v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) (ABL2), transcript variant b is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens ]
Official Symbol : ABL2
Synonyms : ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-related gene protein; ABLL;
Gene ID : 27
mRNA Refseq : NM_001136000
Protein Refseq : NP_001129472
MIM : 164690
UniProt ID : P42684
Chromosome Location : 1q25.2
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem; Signaling by Robo receptor, organism-specific biosystem; Viral myocarditis, organism-specific biosystem;
Function : ATP binding; actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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Which substances are the ligands of ABL2? 05/19/2022

Magnesium, Manganese,Nucleotide, etc.

Where is ABL2 localized? 02/04/2022

ABL2 localization in cytoplasm and cytoskeleton.

Can ABL2 phosphorylate DOK1? 09/18/2021

ABL2 involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35.

Is there any post-translational modification of ABL2? 01/28/2020

ABL2 has polyubiquitination and glycosylation modifications, etc.

What are the functions of ABL2? 10/22/2019

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis.

What is the relationship between abl1 and abl2? 04/15/2018

abl1 is the important paralog of abl2. abl2 plays an abl1-overlapping role in key processes linked to cell growth and survival.

What are the diseases associated with abl2? 12/03/2016

Diseases associated with ABL2 include Leukemia and B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1.

Is this gene expressed in cancer cells? 06/12/2016

This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia.

Customer Reviews (3)

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Reviews
03/16/2022

    The after-sales service is very timely.

    09/22/2020

      Custom products take time, but the quality is really good!

      04/16/2019

        It is the second time to buy your product, very good.

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