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Recombinant Human Kallikrein 1

Cat.No. : KLK1-38H
Product Overview : Recombinant Human KLK1 produced in Yeast is a single, glycosylated, polypeptide chain containing 238 amino acids and having a molecular mass of 28-32 kDa. KLK1 Human Recombinant is purified by proprietary chromatographic techniques.
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Cat. No. : KLK1-38H
Description : KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels. KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1", and Phe/Leu at P2.
Source : Pichia Pastoris
Amino Acid Sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Ile-Val-Gly-Gly-Trp-Glu.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 98.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein solution contains 1X PBS.
Biological Activity : Human Kallikrein-1 active Unit Definitin: 1 unit will hydrolize 1 μmole of H-D-Val-Leu-Arg-pNA(S-2266) per minute at pH 8.0 at 37°C Human Kallikrein-1 measured biological activity of no less than 5 Units/mg (S2266 method).
Stability : KLK1 although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Publication :
Kallikrein–Kinin system suppresses Type i interferon responses: a novel Pathway of interferon regulation (2018)
Gene Name : KLK1 kallikrein 1 [ Homo sapiens ]
Synonyms : kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; Klk6; KLKR; KLK1; hK1; kallikrein 1; tissue kallikrein; glandular kallikrein 1; EC 3.4.21.35; Kidney/pancreas/salivary gland kallikrein
Gene ID : 3816
mRNA Refseq : NM_002257
Protein Refseq : NP_002248
MIM : 147910
UniProt ID : P06870
Chromosome Location : 19q13.3
Function : peptidase activity; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is KLK1 involved in coagulation and fibrinolysis? 08/10/2022

KLK1 participates in the regulation of blood clotting and fibrinolysis by influencing the activation of certain coagulation factors and promoting fibrinolysis.

How does KLK1 impact renal function? 06/06/2020

KLK1 contributes to renal function by promoting vasodilation in the renal blood vessels and influencing sodium and water excretion, which can be beneficial in kidney diseases.

Is KLK1 associated with cancer? 03/26/2020

Some studies suggest that KLK1 may be involved in cancer progression, but the relationship is complex and not fully understood. Further research is needed.

Are there any clinical applications of KLK1 in inflammatory conditions? 05/18/2019

Some studies suggest that KLK1-based therapies may have potential in managing inflammatory conditions, but more research is needed for conclusive evidence.

Are there any KLK1-based therapies for cancer? 02/21/2016

The potential use of KLK1 in cancer therapy is an area of investigation, but no specific KLK1-based cancer therapies have been established yet.

Customer Reviews (3)

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Reviews
04/24/2019

    Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.

    06/30/2018

      Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

      12/12/2017

        This strong track record of excellence further attests to the KLK1 protein's capability to meet the rigorous demands of research projects.

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