Recombinant Human Matrix Metallopeptidase 8
Cat.No. : | MMP8-41H |
Product Overview : | Recombinant Human Matrix Metalloproteinase-8 produced inE.Coliis a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa. The MMP-8 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MMP8-41H |
Description : | Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered clear solution. |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Formulation : | The protein Solution (100 units/ml) in 0.05 M Tris-HCl buffer, pH 7.6, containing 0.2 M NaCl, 5 mM CaCl2, 0.0025% NaN3 and 0.1% BSA. |
Biological Activity : | 100 units/ml after activation with APMA by solution assay method. One unit of collagenolytic activity is defined as the cleavage of 1µg of collagen per minute by the solution method. |
Applications : | Used as a standard for analyzing mammalian collagenase activity. |
Stability : | MMP-8 although stable at 14°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
Gene Name : | MMP8 matrix metallopeptidase 8 (neutrophil collagenase) [ Homo sapiens ] |
Synonyms : | MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; PMNL-CL; PMNL collagenase; matrix metalloproteinase 8; EC3.4.24.34; MMP-8; PMNL-CL; PMNL collagenase; Matrix metalloproteinase-8 |
Gene ID : | 4317 |
mRNA Refseq : | NM_002424 |
Protein Refseq : | NP_002415 |
MIM : | 120355 |
UniProt ID : | P22894 |
Chromosome Location : | 11q22.3 |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
Mmp8-1127R | Recombinant Rat Mmp8 Protein, His&SUMO-tagged | +Inquiry |
MMP8-5437H | Recombinant Human MMP8 Protein, GST-tagged | +Inquiry |
MMP8-3376R | Recombinant Rat MMP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP8-4454H | Recombinant Human MMP8 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mmp8-750R | Recombinant Rat Mmp8 protein, His & T7-tagged | +Inquiry |
◆ Native Protein | ||
MMP8-89H | Native Human Pro-MMP-8 | +Inquiry |
MMP8-1656H | Active Native Human MMP8 Protein | +Inquiry |
◆ Lysates | ||
MMP8-2080MCL | Recombinant Mouse MMP8 cell lysate | +Inquiry |
MMP8-001MCL | Recombinant Mouse MMP8 cell lysate | +Inquiry |
MMP8-2054HCL | Recombinant Human MMP8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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