Recombinant Human CALCR cell lysate
Cat.No. : | CALCR-272HCL |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | CALCR calcitonin receptor [ Homo sapiens ] |
Official Symbol : | CALCR |
Synonyms : | CALCR; calcitonin receptor; CTR; CRT; CT-R; CTR1; |
Gene ID : | 799 |
mRNA Refseq : | NM_001164737 |
Protein Refseq : | NP_001158209 |
MIM : | 114131 |
UniProt ID : | P30988 |
Chromosome Location : | 7q21.3 |
Pathway : | Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; |
Function : | calcitonin binding; NOT calcitonin binding; calcitonin binding; calcitonin receptor activity; calcitonin receptor activity; protein binding; protein transporter activity; receptor activity; receptor activity; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
Calcr-650R | Recombinant Rat Calcr Protein, His-tagged | +Inquiry |
CALCR-0296H | Recombinant Human CALCR Protein, GST-Tagged | +Inquiry |
Calcr-649M | Recombinant Mouse Calcr Protein, His-tagged | +Inquiry |
CALCR-1054HFL | Recombinant Human CALCR protein, His&Flag-tagged | +Inquiry |
CALCR-27793TH | Recombinant Human CALCR | +Inquiry |
◆ Assay kits | ||
Kit-1136 | CALCR CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1137 | CALCR U2OS β-Arrestin GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCALCR is expressed in MTC cells. Measuring CALCR expression can serve as a diagnostic marker for MTC, helping to identify and diagnose this type of thyroid cancer.
The CALCR receptor is the target for calcitonin. When calcitonin binds to CALCR on osteoclasts, it inhibits bone resorption, helping to maintain bone health.
CALCR is specific to calcitonin signaling. Downstream signaling pathways include activation of G proteins, which affect intracellular calcium levels and other signaling molecules.
CALCR activation in osteoclasts inhibits bone resorption, which plays a crucial role in maintaining calcium homeostasis by reducing calcium release from bone.
CALCR activation by calcitonin has been used in the treatment of osteoporosis to inhibit bone resorption, thus helping to maintain bone density.
Customer Reviews (3)
Write a reviewIt's clear that the product is meticulously crafted for laboratory use.
My experiments rely on the consistency of the product, and it hasn't let me down.
The product exceeded my expectations in terms of quality and performance.
Ask a Question for All CALCR Products
Required fields are marked with *
My Review for All CALCR Products
Required fields are marked with *
Inquiry Basket