Recombinant Human CALCRL cell lysate
Cat.No. : | CALCRL-273HCL |
- Specification
- Gene Information
- Related Products
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | CALCRL calcitonin receptor-like [ Homo sapiens ] |
Official Symbol : | CALCRL |
Synonyms : | CALCRL; calcitonin receptor-like; calcitonin gene-related peptide type 1 receptor; CGRPR; CRLR; CGRP type 1 receptor; calcitonin receptor-like receptor; |
Gene ID : | 10203 |
mRNA Refseq : | NM_005795 |
Protein Refseq : | NP_005786 |
MIM : | 114190 |
UniProt ID : | Q16602 |
Chromosome Location : | 2q21.1-q21.3 |
Pathway : | Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; |
Function : | G-protein coupled receptor activity; calcitonin gene-related polypeptide receptor activity; calcitonin receptor activity; protein binding; protein transporter activity; receptor activity; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
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CALCRL-0299H | Recombinant Human CALCRL Protein, GST-Tagged | +Inquiry |
CALCRL-754R | Recombinant Rat CALCRL Protein, His (Fc)-Avi-tagged | +Inquiry |
CALCRL-1090R | Recombinant Rat CALCRL Protein | +Inquiry |
CALCRL-3992C | Recombinant Chicken CALCRL | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCALCRL is a G-protein-coupled receptor (GPCR). It interacts with CGRP by binding to it, initiating intracellular signaling pathways.
CALCRL forms a complex with the receptor activity-modifying protein 1 (RAMP1) to create the functional CGRP receptor, allowing CGRP to exert its biological actions.
CALCRL mediates the biological effects of CGRP, which include vasodilation, pain modulation, and inflammation regulation.
Signaling through CALCRL is specific to CGRP. Downstream pathways include activation of cyclic AMP (cAMP) and intracellular calcium levels, influencing vascular tone and pain perception.
Understanding CALCRL's role in CGRP signaling has led to the development of targeted therapies for migraine and chronic pain, making it a significant area of clinical research.
Customer Reviews (3)
Write a reviewI rely on the product for consistent and reproducible outcomes.
The product is an indispensable part of my lab routine.
The timely delivery of the product was a pleasant surprise.
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