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Recombinant Human CALCRL cell lysate

Cat.No. : CALCRL-273HCL
  • Specification
  • Gene Information
  • Related Products
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : CALCRL calcitonin receptor-like [ Homo sapiens ]
Official Symbol : CALCRL
Synonyms : CALCRL; calcitonin receptor-like; calcitonin gene-related peptide type 1 receptor; CGRPR; CRLR; CGRP type 1 receptor; calcitonin receptor-like receptor;
Gene ID : 10203
mRNA Refseq : NM_005795
Protein Refseq : NP_005786
MIM : 114190
UniProt ID : Q16602
Chromosome Location : 2q21.1-q21.3
Pathway : Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function : G-protein coupled receptor activity; calcitonin gene-related polypeptide receptor activity; calcitonin receptor activity; protein binding; protein transporter activity; receptor activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the chemical structure of CALCRL, and how does it interact with CGRP? 05/08/2022

CALCRL is a G-protein-coupled receptor (GPCR). It interacts with CGRP by binding to it, initiating intracellular signaling pathways.

What is the relationship between CALCRL and the CGRP receptor (RAMP1) in mediating CGRP's effects? 03/05/2022

CALCRL forms a complex with the receptor activity-modifying protein 1 (RAMP1) to create the functional CGRP receptor, allowing CGRP to exert its biological actions.

What is the primary function of CALCRL in relation to CGRP? 08/27/2020

CALCRL mediates the biological effects of CGRP, which include vasodilation, pain modulation, and inflammation regulation.

How does the signaling through CALCRL differ from that through other GPCRs, and what are its downstream signaling pathways? 10/21/2019

Signaling through CALCRL is specific to CGRP. Downstream pathways include activation of cyclic AMP (cAMP) and intracellular calcium levels, influencing vascular tone and pain perception.

What are the clinical applications and significance of studying CALCRL in conditions like migraine and chronic pain? 01/27/2018

Understanding CALCRL's role in CGRP signaling has led to the development of targeted therapies for migraine and chronic pain, making it a significant area of clinical research.

Customer Reviews (3)

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Reviews
05/02/2020

    I rely on the product for consistent and reproducible outcomes.

    07/25/2019

      The product is an indispensable part of my lab routine.

      09/19/2018

        The timely delivery of the product was a pleasant surprise.

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