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Recombinant Human HLA-DRB1 cell lysate

Cat.No. : HLA-DRB1-797HCL
  • Specification
  • Gene Information
  • Related Products
Description : HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [ Homo sapiens ]
Official Symbol : HLA-DRB1
Synonyms : HLA-DRB1; major histocompatibility complex, class II, DR beta 1; HLA DR1B; DW2.2/DR2.2; MHC class II antigen; lymphocyte antigen DRB1; MHC class II HLA-DRw10-beta; human leucocyte antigen DRB1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; HLA class II histocompatibility antigen, DR-1 beta chain; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; FLJ75017; FLJ76359;
Gene ID : 3123
mRNA Refseq : NM_001243965
Protein Refseq : NP_001230894
MIM : 142857
UniProt ID : P01911
Chromosome Location : 6p21.3
Pathway : Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem;
Function : MHC class II receptor activity; MHC class II receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does HLA-DRB1 play in disease susceptibility and progression? 09/05/2022

HLA-DRB1 alleles are linked to susceptibility and progression of various diseases.

What is the significance of HLA-DRB1 polymorphisms in autoimmune diseases? 04/24/2022

Certain HLA-DRB1 alleles are associated with a higher risk of autoimmune diseases.

How does HLA-DRB1 variability impact transplant compatibility? 03/14/2022

Variability in HLA-DRB1 can affect transplant success, with mismatches potentially leading to rejection.

How is HLA-DRB1 expression regulated in immune cells? 01/03/2022

Its expression is tightly controlled, influenced by cytokines and immune signals.

How does HLA-DRB1 contribute to antigen presentation? 10/29/2020

It binds peptides from extracellular proteins, presenting them on the cell surface for T cell recognition.

What is the primary role of HLA-DRB1 in the immune system? 03/11/2019

HLA-DRB1 is crucial for immune responses, presenting peptides to CD4+ T cells.

Are there any therapeutic approaches targeting HLA-DRB1? 02/27/2019

Therapeutic strategies might involve modulating HLA-DRB1 expression or function in autoimmune diseases or transplantation.

Customer Reviews (3)

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Reviews
02/14/2022

    Consistently good quality.

    09/04/2021

      Great product, fast shipping.

      03/30/2020

        Excellent quality, very pure.

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