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Recombinant Human Plasminogen Activator, Tissue

Cat.No. : PLAT-55H
Product Overview : Recombinant Human Tissue Plasminogen Activator produced inCHO cellsis a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59008.71 Dalton. TPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.
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Cat. No. : PLAT-55H
Description : Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
Source : Chinese Hamster Ovary Cells (CHO)
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Each mg of Alteplase contains 1.7 gr L-arginine, 0.5 gr phosphoric acid and 4 mg tween 80.
Solubility : It is recommended to reconstitute the lyophilized t-PA in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Enzymatic Activity : 580,000 IU/mg.
Stability : Lyophilized Reteplase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : PLAT plasminogen activator, tissue [ Homo sapiens ]
Synonyms : PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; Tissue-type plasminogen activator; t-plasminogen activator; t-PA; tPA;INNAlteplase;INNReteplase; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; Alteplase; EC 3.4.21.68; Reteplase; alteplase; reteplase; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
Gene ID : 5327
mRNA Refseq : NM_000930
Protein Refseq : NP_000921
MIM : 173370
UniProt ID : P00750
Chromosome Location : 8p12
Pathway : Complement and coagulation cascades; Hemostasis; Signaling by PDGF
Function : peptidase activity; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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