Recombinant Human JAM2, Fc-tagged

• Cat.No.: JAM2-174H
• Product Overview: Recombinant Human JAM2 /CD322 Protein, With C-Fc Tag (rh JAM2 / CD322 Fc Chimera) Phe 29 - Asn 236 (Accession # AAH17779) was produced in human 293 cells (HEK293).

Specification

• Description: Junctional adhesion molecule B (JAM-B) is also known as Junctional adhesion molecule 2 (JAM-2), Vascular endothelial junction-associated molecule (VE-JAM), CD antigen CD322, which belongs to the immunoglobulin superfamily. JAM-B contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. JAM-B is highest expression in the heart, placenta, lung, foreskin and lymph node. JAM-B may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: rh JAM2 / CD322 Fc Chimera is fused with human IgG1 Fc tag at the C-terminus, and has a calculated MW of 50 kDa. The predicted N-terminus is Phe 29. DTT-reduced Protein migrates as 60-68 kDa in SDS-PAGE due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg of the rh JAM2 / CD322 Fc Chimera by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
• Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.

Gene Information

• Gene Name: JAM2 junctional adhesion molecule 2 [ Homo sapiens ]
• Official Symbol: JAM2
• Synonyms: JAM2; junctional adhesion molecule 2; C21orf43; junctional adhesion molecule B; CD322; JAM B; JAMB; VE JAM; JAM-2; JAM-IT/VE-JAM; vascular endothelial junction-associated molecule; JAM-B; VEJAM; PRO245; VE-JAM
• Gene ID: 58494
• mRNA Refseq: NM_021219
• Protein Refseq: NP_067042
• MIM: 606870
• UniProt ID: P57087
• Chromosome Location: 21q21.2
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Hemostasis, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem
• Function: protein binding; protein heterodimerization activity