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Recombinant Human IFNAR1 protein, Fc-tagged

Cat.No. : IFNAR1-188H
Product Overview : Recombinant Human IFNAR1 (Lys28-Lys436) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Interferon alpha/beta receptor 1 (IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1/IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Lys28
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 73.8 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Lys28-Lys436
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >85% (rh IFNAR1 /IFNAR Fc Chimera) and 13% (Human IgG1 Fc fragment) as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IFNAR1
Official Symbol : IFNAR1
Synonyms : IFNAR1; interferon (alpha, beta and omega) receptor 1; IFNAR; interferon alpha/beta receptor 1; IFRC; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain; AVP; IFNBR; IFN-alpha-REC
Gene ID : 3454
mRNA Refseq : NM_000629
Protein Refseq : NP_000620
MIM : 107450
UniProt ID : P17181

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is IFNAR1 protein targeted in the treatment of autoimmune diseases? 04/17/2023

In the treatment of autoimmune diseases, IFNAR1 protein can be targeted to modulate the immune response and reduce inflammation.

How is IFNAR1 protein used in research settings? 05/29/2022

In research settings, IFNAR1 protein is often studied to better understand its role in immune signaling pathways and disease processes.

How is IFNAR1 protein clinically relevant? 11/18/2021

IFNAR1 protein is clinically relevant in the treatment of diseases such as viral infections, autoimmune diseases, and certain cancers.

Are there any specific drugs that target IFNAR1 protein? 03/03/2019

Yes, there are drugs that specifically target IFNAR1 protein, including some that are used in the treatment of multiple sclerosis and certain viral infections.

What are the potential applications of IFNAR1 protein in cancer treatment? 08/30/2017

IFNAR1 protein may be targeted to enhance the body's immune response against cancer cells, leading to potential immunotherapy applications.

Customer Reviews (3)

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Reviews
12/09/2021

    An additional advantage of selecting the IFNAR1 protein is the outstanding technical support offered by its manufacturer.

    06/05/2020

      The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.

      09/30/2016

        Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

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