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Recombinant Human ERBB3 Protein(Ser20-Thr643), His-Avi-tagged, FITC-Labeled

Cat.No. : ERBB3-207H
Product Overview : FITC-Labeled Recombinant Human ERBB3 Protein(Ser20-Thr643)(P21860), fused with C-terminal His and Avi tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : C-His-Avi
Protein length : Ser20-Thr643
Conjugation/Label : FITC
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized FITC-Labeled Human Her3, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 23.6ng/ml determined by ELISA.
Molecular Mass : The protein has a predicted MW of 71.6 kDa. Due to glycosylation, the protein migrates to 72-75 kDa based on Tris-Bis PAGE result.
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Gene Name : ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]
Official Symbol : ERBB3
Synonyms : ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033
Gene ID : 2065
mRNA Refseq : NM_001005915
Protein Refseq : NP_001005915
MIM : 190151
UniProt ID : P21860

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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Reviews
10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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