Recombinant Human ERBB3 Protein(Ser20-Thr643), His-Avi-tagged, FITC-Labeled
Cat.No. : | ERBB3-207H |
Product Overview : | FITC-Labeled Recombinant Human ERBB3 Protein(Ser20-Thr643)(P21860), fused with C-terminal His and Avi tag, was expressed in HEK293. |
- Specification
- Gene Information
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Source : | HEK293 |
Species : | Human |
Tag : | C-His-Avi |
Protein length : | Ser20-Thr643 |
Conjugation/Label : | FITC |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. |
Bio-activity : | Immobilized FITC-Labeled Human Her3, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 23.6ng/ml determined by ELISA. |
Molecular Mass : | The protein has a predicted MW of 71.6 kDa. Due to glycosylation, the protein migrates to 72-75 kDa based on Tris-Bis PAGE result. |
Endotoxin : | Less than 1EU per μg by the LAL method. |
Purity : | > 95% as determined by Tris-Bis PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Gene Name : | ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Official Symbol : | ERBB3 |
Synonyms : | ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033 |
Gene ID : | 2065 |
mRNA Refseq : | NM_001005915 |
Protein Refseq : | NP_001005915 |
MIM : | 190151 |
UniProt ID : | P21860 |
Products Types
◆ Recombinant Protein | ||
ERBB3-237H | Recombinant Human ERBB3 Protein, Fc-tagged | +Inquiry |
ERBB3-858H | Recombinant Human ERBB3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERBB3-209H | Active Recombinant Human ERBB3(Met1-Thr643), His-tagged | +Inquiry |
ERBB3-236H | Recombinant Human ERBB3 Protein, His-tagged | +Inquiry |
ERBB3-28H | Active Recombinant Human ERBB3 Protein (Ser20-Gly538), C-6×His tagged | +Inquiry |
◆ Lysates | ||
ERBB3-1415RCL | Recombinant Rat ERBB3 cell lysate | +Inquiry |
ERBB3-430HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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