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Recombinant Influenza A H7N9 Hemagglutinin/HA1 protein, His-tagged

Cat.No. : HA-04I
Product Overview : Recombinant Influenza A virus (A/Anhui/1-BALF_RG45/2013(H7N9)) HA1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Source : Insect cell
Species : Influenza A
Tag : His
Form : Liquid
Molecular Mass : 36 kDa (330aa)
Protein length : 19-339
AA Sequence : DKICLGHHAVSNGTKVNTLTERGVE VVNATETVERTNIPRICSKGKRTVD LGQCGLLGTITGPPQCDQFLEFSAD LIIERREGSDVCYPGKFVNEEALRQ ILRESGGIDKEAMGFTYSGIRTNGA TSACRRSGSSFYAEMKWLLSNTDNA AFPQMTKSYKNTRKSPALIVWGIHH SVSTAEQTKLYGSGNKLVTVGSSNY QQSFVPSPGARPQVNGLSGRIDFHW LMLNPNDTVTFSFNGAFIAPDRASF LRGKSMGIQSGVQVDANCEGDCYHS GGTIISNLPFQNIDSRAVGKCPRYV KQRSLLLATGMKNVPEIPKGR
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 95 % by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4) containing 10% glycerol
Official Symbol : HA
Synonyms : Hemagglutinin; HA
UniProt ID : A0A024E3P0
Official Symbol : HA
Synonyms : Hemagglutinin; HA
UniProt ID : A0A024E3P0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How about the structural characteristics of HA protein? 09/14/2019

HA protein is a glycoprotein that contains thousands of carbohydrates and an amino acid chain consisting of 566 amino acid residues. The structure of HA protein has triple symmetry, consisting of three monomers that form a spiral.

Will genetic variants in HA proteins affect vaccine development? 06/06/2019

Genetic variants in the HA protein may affect the development and production of influenza vaccines. Because HA protein is an important component of influenza viruses, different subtypes or variants of HA protein may require different vaccines to prepare.

Why is hemagglutinin protein related to viral replication? 05/17/2019

This protein is one of the key factors in the replication process of influenza viruses. When a virus infects a host cell, the receptor-binding region of the HA protein binds to the receptor on the cell surface, allowing the virus to invade the host cell and replicate.

What are the subtypes of HA protein? 04/01/2019

There are currently 18 known HA subtypes of influenza viruses, H1-H18. Among them, the H1, H2, H3, H5, H7, and H9 subtypes are associated with human viruses, while other subtypes are generally associated with animal viruses.

What are the physiological functions of HA protein? 03/07/2019

The main physiological function of HA protein is to bind to host cells and mediate the entry of influenza viruses into host cells. It contains specific regions that bind glycoprotein receptors that allow the influenza virus to adhere to them. This is an important link that allows the virus to stably bind and enter the cell.

What laboratory techniques are HA proteins used in? 01/07/2019

HA protein is widely used in viral research and drug development. Researchers can use HA proteins to test drugs such as influenza virus activators, antibodies and vaccines, and HA proteins are also widely used to develop novel immunoassays and treatments.

Customer Reviews (2)

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Reviews
06/01/2021

    The transport process does not affect the protein quality, and the stability is good.

    11/27/2019

      Higher solubility makes it easy to prepare the desired concentration.

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