Active Recombinant Human PADI4, Flag-tagged
Cat.No. : | PADI4-20H |
Product Overview : | Human PADI-4, also known as Peptidyl arginine deiminase, type IV, 1-663(end), with C-terminal FLAG-tag, MW= 75 kDa, expressed in a Baculovirus infected Sf9 cell expression system. |
- Specification
- Gene Information
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Description : | This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. |
Source : | Sf9 insect cells |
Species : | Human |
Tag : | Flag |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 80 µg/ml FLAG peptide |
Bio-activity : | ≥80 pmole/min/µg |
Molecular Mass : | 75 kDa |
Purity : | ≥65% |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | >6 months at –80°C. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | PADI4 peptidyl arginine deiminase, type IV [ Homo sapiens ] |
Official Symbol : | PADI4 |
Synonyms : | PADI4; peptidyl arginine deiminase, type IV; PAD; PAD4; PDI4; PDI5; PADI5; protein-arginine deiminase type-4; HL-60 PAD; PADI-H protein; OTTHUMP00000002482; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V |
Gene ID : | 23569 |
mRNA Refseq : | NM_012387 |
Protein Refseq : | NP_036519 |
MIM : | 605347 |
UniProt ID : | Q9UM07 |
Chromosome Location : | 1p36.13 |
Pathway : | protein citrullination |
Function : | arginine deiminase activity; calcium ion binding; protein binding; protein-arginine deiminase activity |
Products Types
◆ Recombinant Protein | ||
Padi4-038M | Recombinant Mouse Padi4 Protein, His-tagged | +Inquiry |
PADI4-0218H | Recombinant Human PADI4 Protein (A2-P663), Tag Free | +Inquiry |
PADI4-3913R | Recombinant Rat PADI4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Padi4-4653M | Recombinant Mouse Padi4 Protein, Myc/DDK-tagged | +Inquiry |
PADI4-6466M | Recombinant Mouse PADI4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PADI4-630HCL | Recombinant Human PADI4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionPADI4 is predominantly expressed in various tissues, including synovial tissues, immune cells, and certain epithelial cells.
PADI4 plays a crucial role in citrullination, a process that converts arginine residues to citrulline, influencing protein structure and function.
Peptidyl arginine deiminase 4 (PADI4) primarily functions in cellular processes, contributing to the post-translational modification of proteins through citrullination.
In the regulation of immune responses, PADI4 is implicated in autoimmune diseases such as rheumatoid arthritis, where it contributes to autoantibody generation.
Dysregulation or abnormal expression of PADI4 is associated with autoimmune disorders, particularly rheumatoid arthritis.
There are potential therapeutic implications related to targeting PADI4 in autoimmune disorders, making it a focus for drug development.
Specific substrates of PADI4 include histones and other proteins, impacting cellular processes like gene regulation and signaling pathways.
Customer Reviews (3)
Write a reviewThe minimal variation across different batches enhanced the repeatability of our results.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.
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