Recombinant Human Adenosine Deaminase

• Cat.No.: ADA-3H

Specification

• Description: ADA, also known as adenosine deaminase, catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. This protein plays an important role in purine metabolism and in adenosine homeostasis. ADA acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
• Species: Human
• Form: Liquid
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: Greater than 90% as determined by Analysis by SDS-PAGE.
• Usage: For Research Use Only! Not For Use in Humans.
• Storage: Store at -20 °C, for extended storage, conserve at -20 °C or -80 °C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week.
• Storage Buffer: Tris-based buffer,50% glycerol

Gene Information

• Gene Name: ADA adenosine deaminase [ Homo sapiens ]
• Official Symbol: ADA
• Synonyms: ADA; adenosine deaminase; adenosine aminohydrolase
• Gene ID: 100
• mRNA Refseq: NM_000022
• Protein Refseq: NP_000013
• MIM: 608958
• UniProt ID: P00813
• Chromosome Location: 20q13.12
• Pathway: C-MYB transcription factor network, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Purine metabolism, organism-specific biosystem
• Function: adenosine deaminase activity; adenosine deaminase activity; hydrolase activity; metal ion binding; protein binding; purine nucleoside binding; zinc ion binding; zinc ion binding