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Active Recombinant Human Neutrophil gela-tinase-associated lipocalin

Cat.No. : LCN2-4H
Product Overview : The NGAL we can provide is humanized recombinant protein , and it has strong immunogenicity.
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Description : Neutrophil gelatinase-associated lipocalin (NGAL) is a 25KD glucoprotein and a new member of lipocalin family with a typical ?-barrel structure of the family. Based on the recent research, the function of NGAL protein may be is to protect and regulate the activity of matrix metalloproteinase-9(MMP-9) and to involve in inflammation and innate immunity reaction. NGAL protein also is a novel iron transporter that mediates a new iron delivery pathway.Acute kidney injury(AKI) is a syndrome characterized by loss of function in a short time ( hours to days ).The scarcity of early biomarker for AKI has hindered our ability to launch the therapy for this disease.Neutrophil gelatinase-assocliated lipocalin( NGAL ) is a high efficient clinical biomarker for AKI. At present , Cystatin C is widely used for AKI clinical diagnosis. However, compared to Cystatin C , NGAL diagnosis value for AKI is much higher .
Source : E.coli
Species : Human
Predicted N Terminal : Gln 21
Form : Liquid
Bio-activity : Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in recombinant human Lipocalin-2.
Molecular Mass : The recombinant human NGAL consists of 197 amino acids. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhLCN2 is approximately 25 kDa as predicted.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95% as determined by SDS-PAGE
Applications : It can be used to prepare high titer anti-NGAL antibody . And at the same time the NGAL protein can also be used as positive control in NGAL diagnosis Kit (renal function analysis , AKI analysis).
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Concentration : 1 mg/ml
Storage Buffer : 20 mM Tris pH 7.5, 20% glycerol
Gene Name : LCN2 lipocalin 2 [ Homo sapiens ]
Official Symbol : LCN2
Synonyms : LCN2; lipocalin 2; lipocalin 2 (oncogene 24p3); neutrophil gelatinase-associated lipocalin; 24p3; neutrophil gelatinase associated lipocalin; NGAL; oncogene 24p3; siderocalin; p25; lipocalin-2; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; MSFI;
Gene ID : 3934
mRNA Refseq : NM_005564
Protein Refseq : NP_005555
MIM : 600181
UniProt ID : P80188
Chromosome Location : 9q34
Function : binding; iron ion binding; transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases are associated with mutations or abnormal expression of the LCN2 protein? 06/19/2022

Mutations or abnormal expression of the LCN2 protein may be associated with a variety of diseases. For example, in hereditary kidney disease, mutations in the uNGAL gene can lead to kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein may also change.

What diseases are LCN2 protein expression levels associated with? 11/15/2020

Studies have shown that the expression level of LCN2 protein is associated with a variety of diseases. For example, in kidney disease, expression levels of the LCN2 protein can be elevated and can be used as one of the biomarkers to assess the extent of kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein can also change.

What is the interaction between the LCN2 protein and other proteins or molecules? 07/22/2020

The interaction between the LCN2 protein and other proteins or molecules is complex. For example, it can participate in lipid metabolism processes by interacting with lipid molecules. In addition, it can interact with other signal transduction molecules to participate in the signal transduction process.

How can the expression level of LCN2 protein be used for disease diagnosis? 04/03/2020

Kidney function can be assessed by measuring the level of uNGAL in urine, and to help diagnose kidney disease, etc. In addition, abnormal levels of LCN2 protein expression can also be used as an indicator to assess the risk and prognosis of other diseases.

How is the activity of LCN2 protein regulated? 02/16/2020

The activity of the LCN2 protein is regulated by a variety of factors. First, its expression level is regulated by gene expression. Secondly, its activity is also regulated by a variety of small molecule compounds, hormones and other substances. In addition, the LCN2 protein can also regulate its activity by interacting with other proteins.

How does the LCN2 protein relate to other biomarkers? 06/06/2019

LCN2 protein has some association with other biomarkers. For example, in kidney disease, expression levels of uNGAL can be used alongside traditional biomarkers such as creatinine to assess kidney function and degree of impairment. In addition, in diseases such as tumors, expression levels of the LCN2 protein may also change and be associated with other biomarkers.

Customer Reviews (3)

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Reviews
05/02/2022

    They have a wide range of products and can always find LCN2 we need.

    03/11/2021

      The reproducibility of LCN2 is almost 100 percent, and the results are very consistent in every experiment or application, which is an important reflection of its excellent quality.

      12/15/2019

        Catalytic activity of LCN2 is really amazing, and every time it is used, it gives an unexpected catalytic effect and its performance is impressive.

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