Recombinant Human IGFBP1, His-tagged

• Cat.No.: IGFBP1-39H
• Product Overview: Recombinant Human IGFBP1 was produced from yeast with the N-terminal His-tag.

Specification

• Description: IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family ,a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP-1 has been shown to modify the short-term effects of IGFs. Acute and chronic elevations in plasma insulin suppress the hepatic production and the circulating level of IGFBP-1, which, in turn, serve to increase the bioavailability of free IGF-I. There is growing evidence that IGFBP-1 and the IGF/IGFBP system may form an important link between the development of hyperinsulinemia/insulin resistance and the development of cardiovascular disease. In the circulation, IGFBP-1 may prevent the adverse IGF-mediated remodeling effect on the vasculature.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
• Molecular Mass: 16 kDa
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -20℃ to -94℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.

Gene Information

• Gene Name: IGFBP1 insulin-like growth factor binding protein 1 [ Homo sapiens ]
• Official Symbol: IGFBP1
• Synonyms: IGFBP1; insulin-like growth factor binding protein 1; IBP1; insulin-like growth factor-binding protein 1; AFBP; alpha pregnancy associated endometrial globulin; amniotic fluid binding protein; binding protein 25; binding protein 26; binding protein 28; growth hormone independent binding protein; hIGFBP 1; IGF binding protein 1; IGF BP25; placental protein 12; PP12; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; IGF-binding protein 1; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin; IGF-BP25; hIGFBP-1
• Gene ID: 3484
• mRNA Refseq: NM_000596
• Protein Refseq: NP_000587
• MIM: 146730
• UniProt ID: P08833
• Chromosome Location: 7p13-p12
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; PERK regulated gene expression, organism-specific biosystem
• Function: insulin-like growth factor binding